Dual-Selector Biphasic Recognition Chiral Extraction for Naproxen Enantiomers: Experimental Evaluation and Molecular-Level Mechanism
A dual-selector biphasic recognition chiral extraction (BRCE) system was developed for the resolution of racemic naproxen using hydrophobic l-di-p-toluoyl-d-tartaric acid (L-DTTA) in the organic phase and hydrophilic hydroxyethyl-β-cyclodextrin (HE-β-CD) in the aqueous phase. Single-selector screening first identifie...