Hong-Yan Guo

Z-Nucleic Acid-Binding Protein (ZBP)1 (DAI/DLM1) Regulation in Antiviral Cell Death Pathways

Metazoan organisms employ an array of overlapping innate and adaptive immune mechanisms to defend against infection and prevent disease. Z-nucleic acid-binding protein (ZBP)1 (also denoted DAI or DLM1) has emerged as a key nucleic acid (NA) sensor within mammalian cells responding to stress, infection or inflammation....