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Hongxing Shen

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Review Open access Oct 2026

Enterovirus 2B protein: From viroporin to membrane stress sensor, mechanistic principles of multi-pathway regulation.

Enterovirus 2B is a highly conserved, functionally versatile, nonstructural protein. The classic viroporin model, which restricts its role to ion channel formation, cannot account for its interactions with host factors such as Bcl-2-associated X protein, interleukin enhancer-binding factor 2, and karyopherin subunit al...

Zeng-Jun Ji, Yi-Kun Chen, Hong-Xing Shen · 0 citations
Open access Aug 2026

Enteroviruses antagonize the host restriction factor ABL2 via proteasomal degradation to facilitate viral replication

Enteroviruses, including Coxsackievirus B3 (CVB3), are significant human pathogens that cause severe diseases, such as viral myocarditis, pancreatitis, and encephalitis. ABL proto-oncogene 2 (ABL2), a non-receptor tyrosine-protein kinase, regulates diverse physiological processes and participates in virus infection; ho...

Mengran Yuan, Xiaorong Qiao, Hua Wang et al. · 0 citations

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