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Author

Hong Tan

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Aug 2026

TvTPPIMI: A Boundary-Aware Dual-View Framework for Predicting PPI-Modulator Interactions.

Protein-protein interactions (PPIs) regulate essential cellular processes and represent an important class of therapeutic targets; however, discovering effective modulators of PPIs remains a formidable challenge. Although deep learning approaches have been widely explored for PPI modulator discovery, many rely on simpl...

Lai-Ying Yang, Jing Chen, Hong Tan et al. · 0 citations
Open access Aug 2026

A unified predictor of protein stability changes across all mutation types via implicit structure learning

UniStab is introduced, an end-to-end framework for predicting stability changes across all mutation types by leveraging the implicit geometric reasoning of a pre-trained folding model and demonstrates state-of-the-art performance, particularly in the challenging scenarios of multi-point mutations and indels.

Hong Tan, Sheng-Geng Lin, Yi Xiong · 0 citations

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