Nasal Exposure to Environmental PM2.5 Drives Testicular Pyroptosis and Tissue Damage: Evidence from Inhibitor Intervention and Multi-Source Data
Abstract Objective: Focusing on the process by which PM2.5 induces NLRP3/Caspase-1 axis activation and drives GSDMD-mediated pyroptosis, this study aimed to construct an integrated framework combining evidence from a PM2.5 animal model, intervention with a pyroptosis inhibitor, and reproducible screening of public tran...