Author

Hong-Ling Jia

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Open access 2026

Single-Cell Immune Microenvironment Atlas of Human Myocardial Infarction Focusing on Myeloid Cells and Functional Differentiation of Macrophage Subtypes

Myocardial infarction (MI) is characterized by extensive immune activation and dynamic remodeling of the cardiac microenvironment, in which myeloid cells play critical roles in regulating inflammation and tissue repair. However, the cellular heterogeneity, developmental trajectories, and intercellular communication...

Zhen-Zhen Zhao, Xu-Heng Dou, Fu Zhao et al. · BIO Integration · 0 citations

Open access Aug 2026

Single-cell transcriptomic landscape delineates pathogenic NK cell subpopulations and key mediators in systemic inflammatory response syndrome

Findings delineate dynamic NK subpopulation remodeling during SIRS and validate IGF1/IGF1R as a potential key pathway governing NK effector function, providing a transcriptomic basis for identifying candidate biomarkers and potential therapeutic targets in SIRS.

Hong-Ling Jia, Hang Zhao, Yan Li et al. · Clinical and Experimental Me... · 0 citations

Review Open access Jul 2026

Diagnostic and therapeutic applications of melanoma-derived exosomes in nanomedicine

This review highlights mechanistic roles of exosomes in melanoma progression, summarizes key liquid-biopsy biomarkers, and discusses translational barriers such as standardization, scalable manufacturing, safety, and clinical validation.

Li Li, Xin Zheng, Jingrui Shi et al. · Microstructures · 0 citations

Open access Aug 2026

Integrative single-nucleus transcriptomic analysis identifies UBE2C+ proliferative tumor cells and immune-stromal regulatory crosstalk in small cell lung cancer

This study identified UBE2C+ proliferative tumor cells as a functionally relevant malignant subpopulation in SCLC and links this state to immune-stromal communication networks within the tumor microenvironment and provides a systems-level framework for investigating the cancer-immunity regulome in SCLC.

Hong-Ling Jia, Yongxuan An, Bing Chen et al. · Frontiers in Immunology · 0 citations