Overall, MERCS dysfunction is proposed as a candidate multimodal upstream hub for calcium, mitochondrial, inflammatory, lipid and ER-stress signalling, and rigorous in-vivo validation together with microglia-selective delivery platforms is essential for therapeutic translation.
An-Nan Liu, Li-Ping Xing, Jian-Hui Li et al.· Ageing Research Reviews· 0 citations
A multidimensional pathological network composed of multiple mitochondrial abnormalities, including mitochondrial reactive oxygen species bursts, Ca2+ overload and disruption of the mitochondrial quality control system, synergistically amplifies lipid peroxidation and drives neuronal ferroptosis across the pathophysiol...
Jian-Hui Li, An-Nan Liu, Wei Gao et al.· Molecular Medicine Reports· 0 citations
Overall, pyroptosis provides a novel framework for understanding the interplay between neuroinflammation and neurodegeneration in AD; however, its cell-type-specific roles, stage-dependent effects, and translational potential remain to be fully elucidated.
Xin-Kai Wu, Qiuyan Ye, Ming-Sheng Zi et al.· Molecular and cellular neuro...· 0 citations
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