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Author

Hongliang Duan

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Jul 2026

HighDB: a structure-annotated cyclic peptide database for comparative analysis, template retrieval, and design-oriented applications

A unified annotation framework for topological and conformational descriptors is provided and HighDB is compared with representative cyclic peptide resources, showing broader annotation coverage and the largest collection of experimentally resolved cyclic peptide structures among the databases examined.

Yi-Qi Xu, Ning Zhu, Tianfeng Shang et al. · 0 citations
Aug 2026

HighMorph: De Novo Cyclic Peptide Sequence Design via Protein-Protein Interaction Recapitulation.

HighMorph is presented, an interaction-guided framework that combines protein–protein interaction information with artificial intelligence for rational cyclic peptide design and provides insights for developing therapeutics targeting challenging protein interfaces.

M. Lan, Chengyun Zhang, Wentong Wang et al. · 0 citations

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