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Hong-Jiang Miao

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Open access Sep 2026

A foundation model learns the sequence and functional grammar of fully human heavy-chain-only antibodies

This work developed HCAbLM, to its knowledge the first foundation model pretrained specifically on a large-scale fully human HCAb repertoire, and its frozen representations transferred to experimentally measured SEC purity, HIC behavior and thermal stability in grouped internal validation and retrospective cross-projec...

Hong-Jiang Miao · bioRxiv · 0 citations