Osteosarcoma is an aggressive bone malignancy with a propensity for pulmonary metastasis, yet the molecular mechanisms linking protein homeostasis to epitranscriptomic regulation remain incompletely understood. Here, integrated transcriptomic, survival, protein-interaction, and CRISPR dependency analyses identified the...
Yan-Fei Wu, Li-Ping Ma, Zhao-Qi Chen et al.· Biochimica et Biophysica Act...· 0 citations
Findings revealed the ETS1/DRP1 axis as a novel pathogenic mechanism and a potential therapeutic target in IVDD and inhibition of ETS1 via AAV5-mediated RNA interference or targeting DRP1 with CRISPR/dCas9-KRAB system or Mdivi-1 alleviated mitochondrial dysfunction, cellular senescence, ECM degradation, and attenuated...
Peng-Fei Li, Yi-Chen Que, Shuhao Zhang et al.· Cellular Signalling· 0 citations
Functional loss‐of‐function experiments demonstrated that silencing (knockdown) of DSCAM‐AS1 expression substantially diminished OS cell proliferation, migration, and invasion, while simultaneously promoting cellular apoptosis in vitro.
Qi Wang, Yun-Zheng Zhao, Long-Bao Shi et al.· Drug development research (P...· 0 citations
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