Simultaneous quantification of venetoclax, selinexor, voriconazole and fluconazole in human plasma by HPLC-MS/MS and its application in hematological malignancies
Background Venetoclax and selinexor are essential targeted agents for hematological malignancies, but their clinical application is challenged by pronounced ethnic pharmacokinetic differences—especially in Chinese patients—and CYP3A-mediated drug-drug interactions (DDIs) with azole antifungals (voriconazole, fluconazol...
Fei-Fei Han, Yin-Ying Wang, Y. Jian et al.
· Frontiers in Pharmacology · 0 citations