Plasmin‑mediated cleavage between SARS-CoV-2 spike protein and ENaC drives pulmonary edema
The high infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) stems from the insertion of four distinct amino acid residues (RRAR), called polybasic cleavage site in the spike (S) protein, that is strikingly identical with that of epithelial sodium channel (ENaC), both of which can be cleaved b...