Author

Hong-Dong Li

2 papers indexed here

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Open access Sep 2026

scMustree: a multi-scale functional hierarchy for single-cell transcriptomic analysis

Abstract Motivation Resolving cellular heterogeneity requires methods that capture both discrete cell types and their functional relationships. Existing single-cell clustering approaches often produce flat partitions, limiting their ability to reveal rare cell states and continuous biological transitions. Here, we intr...

Yun-Pei Xu, Shao-Kai Wang, Li-Qing Ding et al. · Bioinformatics · 0 citations

Open access Sep 2026

TMEDRP: decoding tumor-intrinsic and microenvironmental signatures for clinical drug response prediction

Abstract Motivation Clinical drug response prediction is constrained by the paucity of patient data, forcing a reliance on in vitro cell line models. Current transfer learning-based methods typically focus on learning domain-invariant representations, but often overlook the critical role of tumor microenvironment (TME)...

Ya-Bin Kuang, Hao-Chen Zhao, Yi Luo et al. · Bioinformatics · 0 citations