Disease Progression-dependent Neurobehavioral Phenotypes of Agitation, Anxiety, and Depression in MC903-induced Chronic Itch.
Pruritus is closely associated with anxiety and depression, yet irritability and agitation in chronic itch patients remain poorly characterized in preclinical studies. Using an MC903-induced chronic itch model, we evaluated emotional behaviors across varying durations (7-18 days) and doses (50-100 μM). MC903 induced se...