Crosstalk between α-synuclein accumulation, NLRP3 inflammasome activation, oxidative stress, and apoptosis in a rotenone-induced Parkinson rat model.
Parkinson's disease (PD) is a complex neurodegenerative disorder characterized by the progressive loss of dopaminergic neurons. This study aimed to elucidate the dynamic interplay between these pathological pathways in a rotenone-induced rat model of PD. Adult male Wistar rats were chronically treated with rotenone. Be...