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Hirotaka Iwasaki

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Open access Sep 2026

Nardilysin regulates Slc2a2 expression via an ISLET1-dependent enhancer mechanism in pancreatic β-cells

GLUT2 (Slc2a2) is a key glucose transporter in pancreatic β-cells, and its reduced expression is closely linked to defective glucose-stimulated insulin secretion (GSIS) and diabetes. We previously reported that pancreatic β-cell–specific nardilysin (NRDC)-deficient mice (BetaKO) exhibit a severe diabetic phenotype with...

Kiyoto Nishi, Narangerel Ganbaatar, Mikiko Ohno et al. · 0 citations

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