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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Hiromi Nishimura

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Open access Sep 2026

Excess Met1-linked ubiquitination leads to solid aggregate formation.

The ubiquitin ligase HOIL-1 regulates the formation of Met1-linked (linear) ubiquitin chains through its coordination with the E3 ligase HOIP within the Linear Ubiquitin Chain Assembly Complex (LUBAC). While HOIP-dependent Met1-linked ubiquitination is well established in inflammation and immunity, the physiological im...

Stephanie Kaypee, Minori Miyasaka, T. Nakajima et al. · 0 citations

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