Hideki Tani

Optogenetic and temperature-dependent modulation of vesicular stomatitis virus polymerase activity by an intramolecular dimerizer

Optogenetic dimerization modules are widely used to regulate protein function, yet their behaviour within folded enzymes remains incompletely understood. Here, we engineered vesicular stomatitis virus by inserting an intramolecularly tethered light-inducible dimerizer into the viral RNA-dependent RNA polymerase [large...