Attenuation of liver fibrosis by platelet-type 12S-lipoxygenase expressed in hepatic stellate cells involves repression of platelet-derived growth factor receptors.
Progression of liver fibrosis is a critical determinant of the prognosis of chronic inflammatory liver disease. We previously reported that platelet-type 12S-lipoxygenase localized in hepatic stellate cells (HSCs), which are primary fibrogenic cells in the injured liver, was upregulated in a methionine-choline deficien...