Targeted mutational profiling of Fms-like tyrosine kinase 3, nucleophosmin 1, and isocitrate dehydrogenase 2 in acute myeloid leukemia: Associations with remission, subtypes, and survival
Acute myeloid leukemia is a genetically heterogeneous disease in which genetic alterations play a key role for diagnosis, prognosis, and therapy options. Fms-Like Tyrosine Kinase 3 (FLT3), Nucleophosmin 1 (NPM1), and isocitrate dehydrogenase 2 (IDH2) mutations have clinical significance by influencing the biologi...