Author

Henrique Borges da Silva

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Open access Oct 2026

Cholera toxin remodels intestinal immunity and suppresses systemic metabolism

Cholera toxin (CTx) is a potent enterotoxin and widely used mucosal adjuvant, yet the acute host response to CTx itself, in the absence of a co-administered antigen, remains vague. In this study, we integrated physiological and metabolic phenotyping with intestinal transcriptomics, epithelial imaging, immune profiling,...

A. Roginski, Mahdieh Godazgar, C. L. Salgado et al. · bioRxiv · 0 citations

Open access Jul 2026

Pannexin-1 promotes CD8+ T cell antitumor immunity against colorectal cancer in a gender-dependent way 2256739

Findings suggest PANX1 promotes CD8+T cell-driven anti-tumor immunity in CRC in a gender-dependent manner, potentially explaining sex-based differences.

Alma Banuelos, Henrique Borges da Silva, C. Loureiro · Journal of Immunology · 0 citations

Aug 2026

Astrocytic NFIX regulates thalamocortical circuits through GABA and purinergic signaling.

These studies identify region-specific roles for astrocytic NFIX and its gene regulatory network in TRN astrocytes, while further revealing that astrocytes in the TRN couple regulation of thalamocortical circuit dynamics and memory formation through parallel GABA and purinergic signaling pathways.

Sanjana Murali, Manuel Silva-Pérez, Jun-Sung Woo et al. · Neuron · 0 citations