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Author

Hema Chandra Kotamarthi

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Open access Sep 2026

Topologically complex knotted proteins are processed differentially by ATP‐dependent proteases ClpXP and ClpAP

Knotted proteins can present a distinct topological and mechanical challenge to the AAA+ cellular degradation machineries, determined by the relative size of the knot and the pore dimensions of these enzymes. In this study, we investigated the degradation mechanism of knotted proteins of different topological complexit...

S. Mukherjee, Hema Chandra Kotamarthi · 0 citations
2026

From Condensates to Fibrils: Polyphosphate-Regulated Phase Separation of p53

Protein aggregation is widely associated with neurodegenerative disorders, but increasing evidence suggests that similar misfolding phenomena also contribute to cancer. Although p53 aggregation is commonly associated with oncogenic mutations, wild-type...

Narendran Sekar, Hema Chandra Kotamarthi, Swathi Sudhakar · 0 citations

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