Open access
Sep 2026
Depletion of border-associated macrophages impairs CSF flow and exacerbates extranuclear mutant Huntingtin aggregation in the zQ175DN mouse model of Huntington’s disease
Results indicate that BAMs are non-redundant regulators of CSF flow dynamics at the brain borders, offering a unique non-neuronal therapeutic target to combat HD.
Yan-Li Jiang, Rahul Sondawle, Helen Moniz et al.
· bioRxiv · 0 citations