Sep 2026
6-(2-Hydroxybenzoyl)pyrazolo[1,5-a]pyrimidine-3‑carbonitriles as novel reactive oxygen species-generating anticancer agents inducing ER stress and DNA damage in EGFR-mutant non-small cell lung cancer.
Findings establish HBP-10 as a highly promising anticancer hit compound for the development of next-generation therapeutic agents, targeting ROS-mediated cellular stress in EGFR-mutant NSCLC.
Jiseong Baek, Seunghyun Ahn, Heewon Kang et al.
· Bioorganic & Medicinal Chemi... · 0 citations