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Sponsored AI Networking Cookbook: Practical recipes for AI-assisted network automation and development AI Networking Cookbook: Practical recipes for AI-assisted network automation and development

Author

Heather N. Allen

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Open access Sep 2026

Myotonic Muscle Activity Drives a Persistent Pain State Responsive to NaV1.8-directed Analgesics.

Pain is a common and disabling feature of myotonic disorders, yet its biological basis remains poorly understood and no targeted analgesic therapies currently exist. Here, we demonstrate that skeletal muscle hyperexcitability is sufficient to initiate a persistent pain state independent of inflammation, nerve injury, o...

Tyler S. Nelson, Aida Calderon-Rivera, Heather N. Allen et al. · 1 citation · ⚡1
Open access Sep 2026

Peripheral NaV1.7 modulation reveals divergent peripheral and central adaptations in persistent trigeminal pain

Trigeminal pain produces persistent facial hypersensitivity that is difficult to treat. Ion channels contribute to the pathology of trigeminal pain, but the consequences of their modulation remain poorly understood. We previously demonstrated that voltage-gated sodium channel Nav1.7 is a therapeutic target that can be...

Heather N. Allen, Naomi K. Grabus, Rajesh Khanna · 0 citations
Open access Sep 2026

NaV1.7-dependent peripheral sensitization drives chronic pain in Parkinson’s disease

It is demonstrated that dopaminergic neurodegeneration initiated within the brain is sufficient to drive persistent peripheral sensory neuron dysfunction and identify CRMP2-dependent regulation of NaV1.7 as a therapeutic target for Parkinsonian pain.

Tyler S. Nelson, Naomi K. Grabus, Heather N. Allen et al. · 1 citation

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