Ganoderic acid A attenuates streptozotocin-induced diabetic kidney injury: associations with mitochondrial oxidative stress and TGF-β/Smad signaling.
BACKGROUND Diabetic kidney disease (DKD) involves renal tubular epithelial injury, mitochondrial oxidative stress, and progressive fibrosis. Ganoderic acid A (GAA) has antioxidant and anti-inflammatory activities, but its potential renoprotective effects have not been fully explored in the context of DKD. This study in...