Author

He-Ning Lin

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Open access Aug 2026

Development of GS-441524 derivatives as potent SARS-CoV-2 Mac1 inhibitors via a direct-to-biology approach.

Cocrystal structure of a selected derivative (12p) binding to SARS-CoV-2 Mac1 revealed the binding mode, which will guide future drug development against viral macrodomains.

Ke-Wen Peng, Suryadeep Chakraborty, Shamar D. Wallace et al. · European journal of medicina... · 0 citations