Author

Hazem E. Ghoneim

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Open access Oct 2026

Chronic XBP1s-mediated activation of the unfolded protein response impairs CD8+ T cell anti-tumor immunity

CD8 + T cells play a crucial role in anti-tumor immunity; however, their functionality is compromised by exhaustion driven by chronic antigen exposure, poor tumor microenvironment, and metabolic dysfunction. Activated CD8 + T cells undergo extensive proteomic remodeling, which includes the induction of the IRE1-X...

Keith A. Nair, Jessica Lee, Olivia Zaleski et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

Caspase-11–mediated hyperinflammation impairs CD8+ T cell immunity and viral clearance in severe SARS-CoV-2 infection

Severe SARS-CoV-2 infection is characterized by lung hyperinflammation, impaired IFN responses, and defective T cell activation, yet the molecular drivers of these immune dysregulations remain incompletely understood. Caspase-11 (CASP11), a key effector of the noncanonical inflammasome, has been shown to mediate an inn...

M. Eltobgy, Mohamed M. Shamseldin, Owen D. Whitham et al. · JCI Insight · 0 citations

Jul 2026

Safety and clinical outcomes of a first-in-human trial of point-of-care manufactured trispecific CAR T cells targeting CD19, CD20, and CD22.

A trispecific CAR targeting CD19, CD20, and CD22 with OX40 co-stimulatory domain with overall response rate was 50%, including complete responses in 83% of lymphoma patients, and one-year overall survival rate was 61%, with durable remissions observed in lymphoma.

S. Vasu, N. Denlinger, No-Joon Song et al. · Blood Cancer Discovery · 0 citations

Open access Jul 2026

Decoding Histone-DNA Methylation Crosstalk in Exhausted T Cells to Enhance Immunotherapy 2253691

A central histone—DNA methylation circuit, regulated by KDM5A/B and DNMT3A, that drives epigenetic scarring and terminal exhaustion in CD8 T cells is uncovered and Therapeutic targeting of this circuit offers a novel approach to epigenetically reprogram TEX cells and enhance the efficacy of cancer immunotherapy.

Hazem E. Ghoneim, Amira Yousif, Abbey A. Saadey et al. · Journal of Immunology · 0 citations

Jul 2026

A novel microbial-derived metabolite counteracts exhaustion programming in CD8 T cells 2260531

These findings identify a novel microbial SCFA as a potential metabolic-epigenetic regulator, capable of reactivating effector programs in TEX cells while blocking terminal exhaustion, and provide insights into developing new therapeutic approaches to reprogram TEX cells and enhance the efficacy of T cell immunotherapy...

Asmaa M. Yousif, Amira Yousif, Ava Lowin et al. · Journal of Immunology · 0 citations