Author

Hayoon Park

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Open access Sep 2026

AnnFlux: object-conditioned neural stochastic differential equations for single-cell perturbation dynamics

This framework maps perturbation-driven cell-state evolution as continuous trajectories and represents unseen perturbations using prior-knowledge embeddings and improves distributional fidelity and predicts responses to held-out perturbation combinations.

Hee-Sun Choi, Gaeun Byeon, Hayoon Park et al. · bioRxiv · 0 citations

Molecules and Cells

Genotype-dependent neurodevelopmental phenotypes associated with reduced USP15 dosage are characterized and a human neural framework for investigating ASD-relevant developmental mechanisms in the context of a rare ubiquitin-pathway variant is provided.

Tae-Hwan Park, I. Koh, S. Sung et al. · 0 citations

Open access Aug 2026

AI-driven framework modeling perturbation in brain organoids reveals candidate genes for autism

This framework integrates predicted perturbation effects with genomic evidence to support autism candidate prioritization and identifies a telencephalic neuron-specific model best preserving autism-relevant perturbation structure.

I. Koh, E. Chang, Youngseok Choi et al. · bioRxiv · 0 citations

Open access Jul 2026

USP15 mutation associated with autism spectrum disorder alters progenitor fate and neuronal maturation in human brain organoids.

De novo variants in the ubiquitin-proteasome pathway are linked to autism spectrum disorder (ASD), yet their functional impact on neurodevelopment remains poorly understood. We investigated USP15, a deubiquitinating enzyme with rare damaging variants identified in individuals with ASD, using isogenic human iPSC-derived...

Tae-Hwan Park, I. Koh, Seoyoung Sung et al. · Molecules and Cells · 0 citations