QUANTITATIVE ASSESSMENT OF P53 IMMUNOHISTOCHEMICAL EXPRESSION IS ASSOCIATED WITH ADVERSE CLINICOPATHOLOGIC FEATURES IN P53 WILD-TYPE ENDOMETRIOID ENDOMETRIAL CARCINOMA
Objective: Endometrioid endometrial carcinoma (EEC) generally has a favorable prognosis, yet some cases exhibit aggressive behavior unexplained by standard parameters. Although p53 immunohistochemistry (IHC) primarily serves as a surrogate for TP53 mutations, quantitative variation within the wild-type (wt) category ma...