Author

Hassane S. Mchaourab

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Open access Sep 2026

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development.

Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spanning residues 207-223 of the Pdx1 C-termi...

Anthony S. Wokasch, Muhammad Shamoon, Courtney Campbell et al. · Development · 0 citations

Open access Aug 2026

Enzymatic formation of a conserved isoaspartate in ribosomal protein uS11

Isoaspartate (isoAsp) formation is typically viewed as a “molecular clock” through nonenzymatic degradation of aspartate or asparagine during protein aging. Here we report a nearly universal enzymatic pathway for the formation of a conserved isoAsp in the bacterial ribosomal protein uS11. Proteome-wide protein-protein...

Yanqing Xue, Chandrima Majumdar, Salimat O. Sofela et al. · bioRxiv · 0 citations