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Summary Emerging infectious diseases and late-stage cancers demand rapid, sensitive, and deployable diagnostics. Here, we present HOMEBRED (highly sensitive & specific omnipresent multipurpose endonuclease based reliable detection), a CRISPR-based platform capable of detecting human and animal pathogens (viral/bacteria...
Developmental programs establish tissue identity and organization, but how their reactivation contributes to adult tissue responses remains poorly understood. Here, we identify a functional contribution of apolipoprotein A-I (APOA1), which marks a late fetal colonic epithelial state that reappears after injury. Spatial...
It is proposed that sporadic microsatellite-stable EOCRC and a subset of PCCRC represent sentinel manifestations of a broader, under-recognised process of exposure-related accelerated carcinogenesis, and postulate that cumulative exposures converge to create biologically permissive tissue states that enable accelerated...
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