Oct 2026
Design, synthesis, and biological evaluation of pyrimidine linked fused thiazole–isoxazole conjugates as dual cholinesterase inhibitors for Alzheimer’s disease
Abstract Alzheimer’s disease (AD) affects over 55 million individuals worldwide, yet approved pharmacotherapies remain limited to symptomatic relief. Dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) offers a validated approach to restoring cholinergic tone. However, structurally differen...
Y. Khan, Mujeeb Ul Naeem, Syeda Farwa Naqvi et al.
· Zeitschrift für Naturforschu... · 0 citations