Author

Haruki Horiguchi

2 papers indexed here

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Open access Oct 2026

Hypertensive stress rewires macrophage signaling in heart failure with preserved ejection fraction independent of obesity

Heart failure with preserved ejection fraction (HFpEF) remains a major unmet clinical challenge. Although obesity is common in many HFpEF cohorts from Europe and North America, three Japanese HFpEF cohorts identified hypertension and sympathetic overactivation, rather than obesity, as dominant features. To model thes...

Yuya Kinoshita, Michio Sato, T. Kadomatsu et al. · Nature Communications · 0 citations

Open access Sep 2026

Aging-related IgG accumulation promotes skin inflammation.

Aging skin is characterized by wrinkles, loss of elasticity, and impaired barrier function, largely driven by alterations in dermal fibroblasts and extracellular matrix remodeling. Chronic, age-related inflammation, called inflammaging, is a central activity underlying these changes. Immunoglobulin G (IgG) has recently...

Takehisa Suzuki, Haruki Horiguchi, Shuji Yamamura et al. · Journal of Investigative Der... · 0 citations