CD248/Endosialin regulates synovial fibroblast state to control coupling of inflammation and bone damage in murine models of immune-mediated inflammatory arthritis and ageing.
OBJECTIVE Synovial fibroblasts directly contribute to inflammation and damage in immune-mediated inflammatory arthritis. CD248/Endosialin is expressed by fibroblasts in the synovium, is highly upregulated during inflammation and has been proposed as a potential therapeutic target. This study aimed to map the expression...