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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Haoyu Chen

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Jul 2026

Pristimerin disrupts blood-testis barrier (BTB) integrity via ferroptosis and apoptosis by the NUR77/ATF3/CHOP pathway.

It is demonstrated that Pri directly targets NUR77, activating the NUR77-ATF3-CHOP axis and inducing both apoptosis and ferroptosis in Sertoli cells, leading to spermatogenesis dysfunction, thereby providing critical insights into Pri-induced testicular injury.

Jiaqi Li, Haoyu Chen, Zhengxin Lu et al. · 0 citations

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