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Haoyang Liu

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Open access Aug 2026

Programmable De Novo Design of Mesoporous Protein Crystal Frameworks

Three-dimensional protein crystals are ordered, porous macroscopic materials with potential applications in catalysis, biosensing, and biomedicine. However, most protein crystals are obtained by empirical screening, providing limited control over the lattice architecture, pore geometry or component composition that det...

Zhe Li, Shun-Zhi Wang, W. Sheffler et al. · 0 citations
Open access Aug 2026

Evolution-inspired multi-objective Bayesian optimization for protein engineering

EvoMOBO is established as a modular framework for multi-objective protein engineering using experimental or mechanism-derived labels using simulation-derived mechanistic descriptors, with experiments reserved for final validation.

Kai Wen, Sirui Wang, Yixin Sun et al. · 0 citations

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