Aug 2026
Nanovaccines co-delivering antigen and dual TLR agonists potentiate aged immunity by orchestrating TCR repertoire.
Immunosenescence increases susceptibility to varicella-zoster virus (VZV) infection in the elderly while compromising vaccine responsiveness. Although clinical adjuvants such as AS01 have improved vaccine efficacy, challenges associated with saponin-based components and separate antigen-adjuvant formulations persist. H...
Hao-Lin Chen, Zhi-Hui Zhang, Zhe-Sheng Wen et al.
· Journal of Controlled Releas... · 0 citations