PFArena: Benchmarking Language Models for Protein Modification
The evaluation reveals that model performance shifts systematically with the availability of target-specific experimental evidence: PLMs demonstrate proficiency in open-ended single-mutant generation by leveraging protein-specific priors, whereas LLMs and agents perform strongly in multi-mutant ranking, particularly wh...
Ya-Wen Ouyang, Xin-Bo Zhang, Zi-Yuan Ma et al.
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