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Sep 2026

Integrated Metabolomics, Network Pharmacology, and Experimental Validation Elucidate the Mechanisms Underlying Dingxiang-Guanshitong Decoction in the Treatment of Esophageal Squamous Cell Carcinoma.

INTRODUCTION Esophageal Squamous Cell Carcinoma (ESCC) is a highly aggressive malignancy with limited therapeutic options and poor prognosis, particularly in advanced stages. Dingxiang Guan Shitong Decoction (DGD) is a traditional Chinese medicine preparation that can alleviate symptoms in patients with advanced ESCC....

Ya-Ling Zhang, Dong-Dong Li, Tian-Qing Sang et al. · 0 citations
Open access Sep 2026

Coordinated TNF–NF‐κB and PI3K–Akt Modulation by Yueju Pill in Hashimoto's Thyroiditis: A Network Pharmacology and Molecular Docking Study

ABSTRACT To predict the polypharmacological mechanism of Yueju pill (YJP) against Hashimoto's thyroiditis (HT), this study integrated network pharmacology and molecular docking to develop a computationally derived “dual‐axis core” hypothesis involving the TNF–NF‐κB inflammatory axis and the PI3K–Akt survival/apoptosis...

Hao Zhang, Kuo-Jun Ren, Sheng-Ying Wang · 0 citations

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