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Review Open access Sep 2026

Biomimetic Scaffold‐Based 3D Models for Decoding Cancer Biology and Advancing Therapy

While conventional two‐dimensional (2D) cultures and animal models remain essential tools, they frequently fail to recapitulate the three‐dimensional (3D) architecture, biomechanical cues, and spatial complexity of human tumors, thereby limiting their translational relevance. To address these limitations, scaffold‐base...

Hai-Tao Zhao, Yue-Chen Han, Jie Li et al. · 0 citations
Open access Jul 2026

Integrative single-cell and spatial transcriptomic analysis reveals a lactate-driven crosstalk between NFATc4⁺ tumor cells and SPP1⁺ macrophages in glioblastoma

In vitro functional assays confirmed that NFATc4 knockdown in GBM cells suppressed tumor cell proliferation, migration, and cell cycle while promoting apoptosis, confirming the functional relevance of the NFATc4–SPP1 axis.

Ruo-Li Wang, Wan-Tao Wu, Xuan Wu et al. · 0 citations

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