Jul 2026
Evolution-Aware MSA Reasoning for Subsampling via Factor Graphs
Experiments show that AP-REASONER outperforms baseline subsamplers on structure-sensitive downstream tasks and enables controllable recovery of alternative protein conformations, highlighting the value of modeling MSA subsampling as a controllable optimization problem, where factor-graph reasoning offers an effective alternative to heuristic selection.
Zhangzhi Xiong, Min-Zhang Li, Hao Yu et al.
· arXiv.org · 0 citations