Author

Hao Yang

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Open access Oct 2026

Fusion-loop-engineered Zika mRNA vaccine elicits convergent B cell immunodominance to uncouple protection from ADE in macaques.

Antibody-dependent enhancement (ADE) remains a major hurdle for flavivirus vaccine development. Engineering the fusion loop (FL) represents a promising solution, yet validations restricted to murine models limit human translatability due to profound species divergence. Here, we provide a primate-level demonstration tha...

Chen-Xi Yang, Shu-Xin Guo, Ya-Ming Lu et al. · Cell Reports Medicine · 0 citations

Open access Sep 2026

A dimeric mRNA vaccine based on key-mutant and KP.3 RBDs induces broad-spectrum immunity and protects mice against JN.1 and XDV challenges

The design and preclinical evaluation of SV suggest that heterodimeric RBD architectures incorporating antigenically divergent variants may represent a generalizable platform for countering viral immune evasion, with implications for future SARS-CoV-2 variants and other rapidly evolving viral pathogens.

Jia-Li Xu, Rui Peng, Long-Hai Yuan et al. · Molecular Biomedicine · 0 citations