Hao-Tian Yang

Neurotensin Signaling in Analgesia: Receptor Mechanisms, Targeted Drug Development, and Therapeutic Prospects for Pain and Comorbid Depression.

Opioids are effective for severe pain but are limited by adverse effects and the risk of opioid use disorder (OUD), while non-opioid analgesics may provide insufficient relief. Neurotensin (NT), an endogenous neuropeptide, has attracted interest as a potential analgesic, with encouraging findings mainly from preclinica...