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Sep 2026

Discovery of Oxime Ether Derivatives with High Insecticidal Activity against Plutella xylostella via an Isosteric Ring Exchange Strategy

Nitrogen-containing heterocycles rank among the most prevalent pharmacophores in agrochemicals and are widely utilized for replacing benzene rings during lead compound optimization. A total of 48 novel target compounds were designed and synthesized via structural modification of an oxime ether insecticidal lead previ...

Hao Qian, Gui-Xun Wu, Qiang Zhang et al. · 0 citations
Open access Sep 2026

Design, synthesis, and insecticidal activity of dihydroagarofuran-based oxime ether analogs against Mythimna separata as potential insecticides.

BACKGROUND Agricultural pests significantly reduce crop yields and threaten global food security. Chemical pesticides remain the primary means of pest control. In this study, celangulin V, a plant-derived insecticide, was used as a lead compound. Guided by three-dimensional quantitative structure-activity relationship...

Zi-Yu Wang, Yuan-Yuan Yang, Rong Tang et al. · 0 citations

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