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Hao-Nan Liu

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Open access Sep 2026

Pharmacokinetics, mass balance, and metabolism of [14C]SPH3127 (sitokiren), a novel direct renin inhibitor in humans

Introduction SPH3127 (Sitokiren), a novel direct renin inhibitor used to treat hypertension, is currently approved for marketing in China. The primary objective of this study was to determine the pharmacokinetics, mass balance, and biotransformation of [14C]SPH3127 in humans after the drug was administered to healthy C...

Sheng Ma, Xin-Tong Huang, Shu Yan et al. · Frontiers in Pharmacology · 0 citations

Open access Aug 2026

Analysis of Stress Evolution Characteristics and Mine Pressure Patterns During Roadway Excavation Under Irregular Goaf Areas

To clarify the stage-dependent stress superposition in gob-side roadways beneath irregular overlying goafs, the #52109 material roadway was investigated using a MATLAB-based analytical stress-transfer model, key-strata mechanics, FLAC3D simulation, and field monitoring. The analytical results revealed an approximately...

Hao-Nan Liu, Yi-Bo Wen, Chao-Rui Jiang et al. · Symmetry · 0 citations