Author

Hao-Lin Tang

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Review Open access Sep 2026

HIV-driven tumor ecosystem: from chronic immune dysfunction to cancer evolution

This review comprehensively examines the components and dynamic changes within the tumor ecosystem of HIV-infected patients, focusing on how HIV-mediated CD4+ T-cell depletion, immune checkpoint dysregulation, chronic antigenic stimulation, and direct effects of viral proteins such as Tat and Nef facilitate tumor immun...

Guang Zhou, Juan-Yan Liao, Hao-Lin Tang et al. · Frontiers in Microbiology · 0 citations

Jul 2026

Structure-Guided Optimization of p62-Directed AUTOTACs for Efficient EGFR/VEGFR2 Degradation and Antitumor Efficacy.

Receptor tyrosine kinases (RTKs) are core cancer therapeutic targets, yet their integral membrane localization hinders efficient degradation by traditional ubiquitin-proteasome system (UPS)-based targeted protein degradation (TPD) strategies. Herein, we describe the structure-guided development of p62/SQSTM1-directed a...

Defa Wu, Yongya Wu, Min Zhao et al. · Journal of Medicinal Chemist... · 0 citations