Oct 2026
A synthetic cationic thiopyrylium compound exploits preferential phosphatidylserine recognition to exert antifungal activity.
Findings reveal a mechanism of action in which preferential binding to PS dysregulates fungal lipid homeostasis rather than lysing the membrane, and define IMB-G3 as a promising lead compound for a novel class of antifungal therapeutics.
Bing-Chen Li, Jing Zhang, Shu-Yi Si et al.
· Bioorganic chemistry (Print) · 0 citations