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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Hao-Feng Ye

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Sep 2026

Development of Isoform-Selective GRP78 Inhibitors from a Direct-to-Biology Strategy

The development of isoform-selective HSP70 inhibitors remains challenging due to the high conservation of this chaperone family. Continuing our efforts to target the peptide-binding pocket within the substrate-binding domain (SBD) of GRP78 (BiP/HSPA5), we identified compound 12 using a Direct-to-Biology (D2B) strateg...

Xiao-Yi Zhu, Qiu Li, Ke Wang et al. · 0 citations

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