Review
Aug 2026
Targeting SIRT6: the design and therapeutic implications of activators and inhibitors.
Sirtuin 6 (SIRT6) is an NAD+-dependent deacylase that maintains genomic stability, regulates metabolism, and influences aging, making it an attractive but challenging therapeutic target. Pharmacological modulation of SIRT6 holds promise for cancer and metabolic disorders, yet its context-dependent functions demand prec...
Yuxin Shi, Xiaofan Han, Xin-Qi Li et al.
· Bioorganic & Medicinal Chemi... · 0 citations